A Protective Role of Arecoline Hydrobromide in Experimentally Induced Male Diabetic Rats

Figure 5

Transmission electron micrographs of arecoline-treated and untreated Leydig cells. (a) Untreated rats showing ovoid euchromatic nucleus (N) with smooth endoplasmic reticulum (SER), dense core vesicles (DCVs), and a few clear vesicles (CVs). (b) Arecoline-treated animals showing enlarged nucleus (N) with abundance of SER, DCVs, and CVs. (c) Alloxan treatment of rats showed indented hyperchromatic and pycnotic nucleus (N) with scanty SER and DCVs in the Leydig cells. (d) Arecoline treatment of alloxan-induced diabetic rats indicating hyperactive Leydig cells with enlarged nucleus (N), conspicuous SER, and several DCVs. Scale bars: 1 μm (a, b, and d) and 1.5 μm (c).

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