Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets

Figure 7

Conserved and variable pathogenicity islands in H. pylori. Putative pathogenicity islands predicted in H. pylori. The H. pylori 26695 a reference genome is selected for analysis (scaffold). All the genomes are aligned and a phylogenetically related nonpathogenic organism Wolinella succinogenes DSM 1740 is also included for comparison. PAIs 2, 4, 14, and 15 are found conserved ((a), (b), (c), and (d)). On the other side, PAIs PiHps 8, 13, and 9 ((e), (f), and (g)) were found variable among H. pylori genomes.

(a)

(b)

(c)

(d)

(e)

(f)

(g)