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BioMed Research International
Volume 2015, Article ID 139580, 17 pages
Research Article

Pan-Genome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets

1Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan
2Laboratory of Cellular and Molecular Genetics, Federal University of Minas Gerais (UFMG), 31907-270 Belo Horizonte, MG, Brazil
3Department of Bioinformatics, Mohammad Ali Jinnah University (MAJU), Sehala Road, Islamabad 44000, Pakistan
4KIMS, Khyber Medical University, Peshawar 25000, Pakistan
5Federal University of Pará, 66075-110 Belém, PA, Brazil
6Laboratory of Aquatic Animal Diseases (AQUAVET), Department of Preventive Veterinary Medicine, Federal University of Minas Gerais, 31907-270 Belo Horizonte, MG, Brazil
7Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal 721172, India
8Centre for Biological Sequence Analysis (CBS), Technical University of Denmark, 2800 Kongens Lyngby, Denmark

Received 3 February 2014; Revised 11 July 2014; Accepted 11 July 2014

Academic Editor: Angel Cataldi

Copyright © 2015 Amjad Ali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary data provides insight view to results originally extracted from different tools and databases. Because of availability of large dataset it was not possible to incorporate all of it the article. You can access the additional files having the composition of core genome families of all 1193 genomes (Additional file 1). Additional file 2 contains BLAST data extracted from DEG, number of homologs along with their AC number against all query proteins. Additional file 3 contains BLAST result of gene families against Human genome to find non-human homologs.

Protein sequence of all gene families has been provided in Additional file 4.

Additional file 5 gives a comprehensive view of all predicted epitopes along with their location and their predictions as antigenic or not.

  1. Supplementary Material