Biotechnological Aspects and Perspective of Microbial Keratinase Production

Figure 6

Basic strategy for statistical optimization of keratinase. (a) Response surface methodology perturbation plot; (b) mixture trace plot. Response surface methodology is a collection of statistical techniques for designing experiments, building models, and evaluating the effective factors. It is an efficient statistical technique for optimization of multiple variables to predict best performance conditions with minimum number of experiments.

(a)

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