Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth

Figure 2

Conditional inactivation of Furin in the livers of ASV-B mice resulted in an increased tumor mass. (a) Conditional inactivation of Furin in the livers of ASV-B mice had a significant impact on the tumorigenic process. Already after 5 weeks the ratio of the tumor weight and the total body weight was significantly increased (27%) in the Furin KO mice. Student’s t-test was used to determine statistical significance (–14). (b) A representative photograph of 19-week-old ASVB^+/− Alb-Cre^−/−   mice. (c) A representative photograph of 19-week-old ASVB^+/− Alb-Cre^+/−   mice.

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