Review Article

Regulated Control of the Assembly and Diversity of LPS by Noncoding sRNAs

Table 1

Known and predicted sRNAs involved in LPS biosynthesis and its modifications.

sRNATargetEffect on LPSReference(s)

GlmY/GlmZGlmSGlcN6P precursor of LPS[35, 39, 40]
MicARepression of PhoP/QP-EtN addition to the second Kdo[21, 25]
ā€‰Repression of WaaRSwitch between glycoforms IV and V[25]
ā€‰Repression of LpxT Incorporation of lipid A modifications[24]
GcvBRepression of PhoP/QDirect effect on LPS not known[68]
RybBRepression of WaaRMajor control of the synthesis of glycoforms with truncation in the outer core and incorporation of the third Kdo[25]
SlrARepression of LppLevels of fatty acid (phospholipids vs LPS) control[9, 22]
MgrRRepression of EptBRepression of P-EtN incorporation on the second Kdo[25, 56]
ArcZRepression of EptBImpact on LPS not known[57]
MicFLpxRDeacylation of lipid A[69]
GadYwaaQ operonOverexpression causes transcriptional reduction, direct effect on transcription duo to base-pairing not know[70]
RyeALpxMPredicted from microarray data[71]
RdlAEptAPredicted from microarray data[71]
RyjBRfaHPredicted from microarray data[71]