Subchronic Arsenic Exposure Induces Anxiety-Like Behaviors in Normal Mice and Enhances Depression-Like Behaviors in the Chemically Induced Mouse Model of Depression

Figure 3

The effects of subchronic arsenic exposure on TST and FST behavior tests. Normal mice and reserpine pretreated mice treated with 10 mg/L arsenic or drinking water alone were analyzed by the tail suspension test (TST) and forced swimming test (FST) at 4 and 8 weeks. The total duration of immobility (in seconds) in the tested mice was measured on the TST (a) during the 8-minute period and FST (b) in a 5-minute swim session, alternatively. Each value/error bar is expressed as the mean ± SD of 8 mice. , , significant difference compared with normal control group. , significant difference from the reserpine group (Res).

(a)

(b)