Research Article
Subchronic Arsenic Exposure Induces Anxiety-Like Behaviors in Normal Mice and Enhances Depression-Like Behaviors in the Chemically Induced Mouse Model of Depression
Figure 4
The influence of subchronic arsenic exposure on cell proliferation of cerebral PFC neuron. Cerebral PFC was isolated and studied for histopathology 8 weeks after treatment with drinking water alone (a) and 10 mg/L arsenic (b) in normal mice and drinking water alone (c) and 10 mg/L arsenic (d) in reserpine pretreated mice. The representative staining photomicrographs of PCNA-positive cells in each section were examined (magnification ×40) under light microscopy (scale bar = 200 μm). After 5 random fields from each section were captured, the number of intensely PCNA-positive cells (in brown) in corresponding proliferative zone (including the ventricular and subventricular zones) within each field was computed by using Image Pro Plus software (Version 5.1) and was compared to the total number of cells.
| (a) Water alone |
| (b) As2O3 |
| (c) Res |
| (d) Res + As2O3 |