Table 5: A summary of HRs for the overall and subgroup analyses of SALP and OS of osteosarcoma patients.

Number of studiesPatients numberHR (95% CI)Heterogeneity
Chi-squared value

Overall1722721.82 (1.61–2.06)13.680%0.622
Age
 Preadult and adult1420881.82 (1.60–2.06)10.830%0.625
 Preadult only31841.87 (1.20–2.91)2.842.96%0.242
Enneking stage
 II79101.75 (1.42–2.15)3.530%0.740
 II-III812111.77 (1.61–2.06)6.020%0.538
 III21512.67 (1.75–4.06)0.710%0.400
Sample size
 <100117512.13 (1.70–2.66)10.948.6%0.362
 >100615211.71 (1.48–1.98)0.200%0.999
Geographic region
 Asia67341.89 (1.55–2.31)4.160%0.527
 Non-Asia1115381.78 (1.53–2.07)9.290%0.505

HR: hazard ratio, OS: overall survival, and CI: confidence interval.