Table 6: A summary of HRs for the overall and subgroup analyses of SALP and EFS of osteosarcoma patients.

Number of studiesPatients numberHR (95% CI)Heterogeneity
Chi-squared value

Overall77521.97 (1.61–2.42)7.6521.6%0.265
Age
 Preadult and adult43851.90 (1.45–2.48)5.3343.7%0.149
 Preadult only33672.07 (1.51–2.83)2.157.1%0.341
Enneking stage
 II33211.88 (1.29–2.73)1.910%0.386
 II-III22921.63 (1.19–2.23)1.3224.3%0.250
 III21392.77 (1.88–4.09)0.010%0.906
Sample size
 <10053062.28 (1.68–3.09)6.0934.3%0.193
 >10024461.75 (1.33–2.31)0.020%0.89
Geographic region
 Asia21122.34 (1.19–4.60)1.3425.2%0.248
 Non-Asia56401.94 (1.56–2.40)6.0533.8%0.196

HR: Hazard ratio, EFS: event-free survival, and CI: confidence interval.