PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy

Figure 3

Intracranial injection of Aβ25-35 impaired the learning abilities of C57 mice in the MWM. (a) The mean escape latencies of the mice in the place navigation test. (b) The numbers of platform area crossings in the probe trials. (c) The times spent in the target quadrant in the probe trials. (d) Representative ultrastructural appearance of autophagic vacuoles (AVs, arrows) in mice hippocampus of each group. As shown in TEM pictures of saline group, there was barely any accumulation of autophagic vesicle in axons. Low-dose Aβ25-35 group showed significant accumulation of AVs, while high-dose Aβ25-35 group depicted more AVs than low-dose group. .

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