The Potential of GMP-Compliant Platelet Lysate to Induce a Permissive State for Cardiovascular Transdifferentiation in Human Mediastinal Adipose Tissue-Derived Mesenchymal Stem Cells

Figure 4

Evaluation of p300 and SIRT-1 gene expression by RTPCR of ADMSCs derived from Patient 3 and stimulated with 10% GMP-compliant platelet lysate. The graphs show that the treatment with platelet lysate but not with FBS is able to increase mRNA expression levels of both p300 (a) and SIRT-1 (b) after 6 hours, rapidly decreasing and fluctuating around the baseline. PL, platelet lysate.

(a)

(b)