HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases

Figure 2

ROC curve for biochemical iron markers TS, serum ferritin and iron and diagnosis for HFE-HH genotypes. The cutoff values for the diagnosis of HH were TS > 82%, serum ferritin levels >2685 ng/mL, and serum iron levels >178 μg/dL. The areas under the curve (AUC) were 0.734, 0.643, and 0.719, respectively. It is important to stress that TS showed a higher accuracy when compared to serum iron levels. Conversely, ferritin presents with the lowest accuracy, as demonstrated by the lower AUC.