HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases
Table 3
Clinical manifestations in patients.
Clinical manifestation
HFE-HH ( = 16)
Non-HFE-HH iron elevation ( = 92)
value
Arthropathy
7/13 (53.8)
7/44 (15.9)
0.008
Cardiopathy
10/14 (71.4)
23/36 (63.8)
0.500
Cirrhosis
12/16 (75.0)
58/92 (63.0)
0.316
Hepatocellular carcinoma
5/16 (31.2)
6/85 (7.06)
0.008
Skin hyperpigmentation
4/10 (40.0)
15/55 (27.2)
0.331
Diabetes
9/16 (56.2)
27/90 (30.0)
0.040
Hypogonadism
5/13 (38.4)
9/61 (14.7)
0.056
Osteoporosis
8/11 (72.7)
9/28 (32.1)
0.026
Thyroidopathy
4/16 (25.0)
10/88 (11.3)
0.142
Data are presented as number of patients affected/total number of individuals assessed (%). HFE HH: HFE hereditary hemochromatosis. Non-HFE-HH iron elevation: patients with iron elevation not related to HFE-HH genotypes.