Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus

Figure 3

MSC administration prevents renal ultrastructural alterations. Electron photomicrographs of representative glomeruli from normal mice (a and b), DM mice (c and d), and DM + MSCs mice (e and f), showing marked (c) and moderate (f) increase of extracellular mesangial matrix, overt irregularities and thickening of the GBM (d), and persistent “hump like” protrusions (f). Picture magnification: (a), (c), and (e) ×6,000; (b), (d), and (f) ×16,500. Bars magnifications: (a), (c), and (e) 2,000 nm; (b), (d), and (f) 1,000 nm.