Protein Complex Discovery by Interaction Filtering from Protein Interaction Networks Using Mutual Rank Coexpression and Sequence Similarity

Table 2

Evaluation measurements.

Measurement	Abbreviation	Equation
Sensitivity	Sens.	TP/(TP + FN)
Specificity	Spec.	TN/(TN + FP)
Precision	Prec.	TP/(TP + FP)
-measure	Fm.	(2 Prec. Sens.)/(Prec. + Sens.)
Accuracy	Acc.	(TP + FN)/(TP + TN + FP + FN)

TP: true positives, FP: false positives, TN: true negatives, and FN: false negatives. TP: the number of known proteins (CORUM protein complex) that have not been properly removed by the filtering method. FN: the number of known proteins that have erroneously been deleted by the filtering method. FP: the number of unknown proteins that are not removed by the filtering method. TN: the number of unknown proteins that are removed by the filtering method.