BioMed Research International / 2015 / Article / Tab 4

Research Article

CK2 Secreted by Leishmania braziliensis Mediates Macrophage Association Invasion: A Comparative Study between Virulent and Avirulent Promastigotes

Table 4

Effect of CK2 modulators on the interaction between the L. braziliensis avirulent strain and macrophages.

AdditionAddition during interaction courseAvirulent pretreated parasitesPretreated macrophages
Association index ± SE% interactionAssociation index ± SE% interactionAssociation index ± SE% interaction

None91.69 ± 2.08100.0091.78 ± 2.11100.0091.68 ± 1.64100.00
TBB (1 μM)76.89 ± 1.27**83.8671.83 ± 1.94*78.2683.96 ± 1.9291.58
Heparin (10 μg/mL)62.99 ± 0.80*68.7053.56 ± 0.91*54.7773.28 ± 1.34*79.93
Spermine (500 mM)97.43 ± 1.11106.26109.25 ± 0.72*119.0376.35 ± 0.95*83.28

The reactions were performed as described in Section 2. The values are presented as the mean of 3 independent experiments conducted in triplicate (* indicates P ≤ 0.009 and ** indicates P ≤ 0.05 compared with control without addition; one-way ANOVA, Tukey’s post hoc test).

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