Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults

Table 2

GyrA mutations in Enterobacteriaceae isolated from children and adults.

Mutation	CIP-resistant strains			CIP-nonresistant strains
	( = 94)			( = 46)
	Children%	Adults%	P value	Children%	Adults%	P value
	( = 38)	( = 56)		( = 23)	( = 23)
Ser83 → Leu + Asp87 → Asn	73.7 (28)	67.9 (38)	0.5444	21.7 (5)	8.7 (2)	0.4140
Ser83 → Leu	18.4 (7)	0 (0)	0.0012^*	17.4 (4)	13.0 (3)	1.0000
Ser83 → Ile	0 (0)	19.6 (11)	0.0026^*	0 (0)	4.3 (1)	1.0000
Ser83 → Thr	2.6 (1)	0 (0)	0.4043	0 (0)	8.7 (2)	0.4889
Ser83 → Phe + Asp87 → Ala	0 (0)	3.6 (2)	0.5132	0 (0)	0 (0)	—
Ser83 → Leu + Asp87 → Tyr	0 (0)	3.6 (2)	0.5132	0 (0)	0 (0)	—
Ser83 → Tyr	0 (0)	1.8 (1)	1.0000	0 (0)	0 (0)	—
Asp87 → Asn	2.6 (1)	0 (0)	0.4043	0 (0)	0 (0)	—
Ser83 → Leu + Asp87 → His	0 (0)	1.8 (1)	1.0000	0 (0)	0 (0)	—
Ser83 → Phe	0 (0)	0 (0)	—	0 (0)	4.3 (1)	1.0000
No mutation	2.6 (1)	1.8 (1)	1.0000	60.9 (14)	60.9 (14)	1.0000

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