Development of Monoclonal Antibodies in China: Overview and Prospects

Figure 1

The development progress of antibody technology and antibody drug (date current as December 2014). Notes: 2014: Ramucirumab (VEGFR-2), Siltuximab (IL6), and Vedolizumab (α4β7). 2013: Itolizumab (CD6) [Ind], Ado-trastuzumab emtansine (HER2), and Obinutuzumab [CD20]. 2012: Pertuzumab (HER2). 2011: Belimumab (BLyS), Ipilimumab (CTLA-4), and Brentuximab (CD30), (CD25), and (TNF). 2010: Tocilizumab (IL6R) and Denosumab (RANK-L). 2009: Golimumab (TNR), Canakinumab (ILIb), Catumaxomab (EPCAM/CD3), Ustekinumab (IL12/23), and Ofatumumab (CD20). 2008: Certolizumab (TNF), (EGFR). 2007: Eculizumab (CD5). 2006: Ranibizumab (VEGF), Panitumumab (EGFR), and (HA18G/CD147). 2005: (TNF). 2004: Cetuximab (EGFR), Bevacizumab (VEGF), and Natalizumab (α-4integrin). 2003: I-Tositumomab (CD20), Omalizumab (IgE), Efalizumab (CdIIa), Alefacept (CD2), and (IL-8). 2002: Adalimumab (TNF) and In/90-Ibritumomab (CD20). 2001: Alemtuzumab (CD52). 2000: Gemtuzumab (CD33). 1999: (CD3). 1998: Basiliximab (IL2R), Palivizumab (RSV), Infliximab (TNF), Trastuzumab (HER2), and Etanercept (TNF2). 1997: Rituximab (CD20) and Daclizumab (IL2R). 1996: N/A. 1995: Edrecolomab (EPCAM). Domestic mAb product of China.