Lespedeza davurica (Lax.) Schindl. Extract Protects against Cytokine-Induced β-Cell Damage and Streptozotocin-Induced Diabetes

Figure 6

Immunohistochemical (IHC) and H&E staining of pancreatic islets in STZ-induced diabetic rats. Pancreases were obtained from control ((a), (e)), diabetic control ((b), (f)), LD-treated diabetic group ((c), (g)), and TLB-treated diabetic group ((d), (h)). Islets and adjoining exocrine regions were stained with H&E ((a)–(d)). Islets were labeled with an anti-insulin antibody and peroxidase-labeled anti-rabbit IgG ((e)–(h)). Scale bar is 100 μm. LD (L. davurica) and TLB (tolbutamide) were administered at a dose of 250 mg/kg BW for 4 weeks.

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