Development of a Model of Chronic Kidney Disease in the C57BL/6 Mouse with Properties of Progressive Human CKD
Development of hypertensive proteinuria in Ang II/DOCA salt model of CKD in the C57BL/6 mouse. For all graphs, indicates a significant difference between two groups where . For (a)–(d), □ signifies pretreatment, whereas ■ signifies 21-day posttreatment with Ang II/DOCA. (a), (b) Changes in systolic and diastolic blood pressure in response to Ang II/DOCA. (c), (d) Total 24 h urinary protein and albumin excretion with Ang II/DOCA treatment. (e) Time-course development of proteinuria, expressed as total 24-hour protein excretion at days 7, 14, 18, and 21 posttreatment with Ang II/DOCA.