Genetic Diversity of Mycobacterium tuberculosis Complex Isolated from Tuberculosis Patients in Bahir Dar City and Its Surroundings, Northwest Ethiopia
Table 1
Demographic and clinical characteristics of the study subjects and their association with spoligotype clustering and major lineages ().
Characteristics
Number of isolates, (%)
Number of isolates clustered versus unique ones
Major lineages by CBN
Clustered
Unique
Clustering rate
value
EA
EAI
IO
MA
MB
value
Patient origin (zonal)
0.502
0.822
North Gondar
2 (1.19)
1
1
0.6
1
1
0
0
0
South Gondar
57 (33.9)
29
28
17.3
27
18
3
7
2
East Gojjam
24 (14.3)
12
12
7.14
13
9
1
1
0
West Gojjam
43 (25.6)
29
14
17.3
19
18
0
6
0
Bahir Dar Special
20 (11.9)
13
7
7.74
15
4
0
1
0
Awi
20 (11.9)
12
8
7.14
10
7
2
1
0
North Wollo
2 (1.19)
2
0
1.19
1
1
0
0
0
Age (years)
0.181
0.277
18–28
83 (49.4)
47
36
28
43
30
0
10
0
29–39
41 (24.4)
28
13
16.7
19
16
2
3
1
40–50
20 (11.9)
13
7
7.74
13
4
2
1
0
>50
24 (14.3)
10
14
5.95
11
8
2
2
1
Sex
0.175
0.674
Male
80 (47.6)
51
29
30.4
41
27
3
9
0
Female
88 (52.4)
47
41
28
45
31
3
7
2
Household size
0.855
0.876
4
85 (50.6)
49
36
29.2
42
31
2
9
1
>4
83 (49.4)
49
34
29.2
44
27
4
7
1
TB category
0.943
0.93
Retreatment
26 (15.5)
15
11
8.93
15
8
1
2
0
New
142 (84.5)
83
59
49.4
71
50
5
14
2
Family TB history
0.266
0.758
Yes
46 (27.4)
30
16
17.9
26
14
1
5
0
No
122 (72.6)
68
54
40.5
60
44
5
11
2
Clinical presentation
0.867
0.16
EPTB
114 (67.9)
67
47
39.9
53
43
6
10
2
PTB
54 (32.1)
31
23
18.5
33
15
0
6
0
Total
168 (100)
98
70
58.3
88
58
6
16
2
EA: Euro-American; EAI: East-African Indian; IO: Indo-Oceanic; MA: M. africanum; MB: M. bovis; CBN: conformal Bayesian network; values were presented at 95% confidence interval and considered statistically significant.
