Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 175291, 8 pages
http://dx.doi.org/10.1155/2015/175291
Research Article

Ox-LDL Induces Dysfunction of Endothelial Progenitor Cells via Activation of NF-B

1Department of Cardiology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China
2Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350112, China

Received 21 August 2014; Accepted 25 September 2014

Academic Editor: Ji Li

Copyright © 2015 Kang-ting Ji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. R. S. Packard and P. Libby, “Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction,” Clinical Chemistry, vol. 54, no. 1, pp. 24–38, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. P. J. Barnes and M. Karin, “Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases,” The New England Journal of Medicine, vol. 336, no. 15, pp. 1066–1071, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. S. S. Makarov, “NF-κb as a therapeutic target in chronic inflammation: Recent advances,” Molecular Medicine Today, vol. 6, no. 11, pp. 441–448, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Tirziu, I. M. Jaba, P. Yu et al., “Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching,” Circulation, vol. 126, no. 22, pp. 2589–2600, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. M. E. Davis, I. M. Grumbach, T. Fukai, A. Cutchins, and D. G. Harrison, “stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor κB binding,” Journal of Biological Chemistry, vol. 279, no. 1, pp. 163–168, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Hoshi, M. Goto, N. Koyama, K.-I. Nomoto, and H. Tanaka, “Regulation of vascular smooth muscle cell proliferation by nuclear factor-κB and its inhibitor, I-κB,” The Journal of Biological Chemistry, vol. 275, no. 2, pp. 883–889, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Rogler, K. Brand, D. Vogl et al., “Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa,” Gastroenterology, vol. 115, no. 2, pp. 357–369, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. B. M. Necela, W. Su, and E. A. Thompson, “Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor γ and nuclear factor-κB in macrophages,” Immunology, vol. 125, no. 3, pp. 344–358, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. S. Penn and G. M. Chisolm, “Oxidized lipoproteins, altered cell function and atherosclerosis,” Atherosclerosis, vol. 108, pp. S21–S29, 1994. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Steinberg and J. L. Witztum, “Lipoproteins and atherogenesis: current concepts,” Journal of the American Medical Association, vol. 264, no. 23, pp. 3047–3052, 1990. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Kita, N. Kume, M. Yokode et al., “Oxidized-LDL and atherosclerosis role of LOX-1,” Annals of the New York Academy of Sciences, vol. 902, pp. 95–102, 2000. View at Google Scholar · View at Scopus
  12. T. Kita, N. Kume, M. Minami et al., “Role of oxidized LDL in atherosclerosis,” Annals of the New York Academy of Sciences, vol. 947, pp. 199–205, 2001. View at Google Scholar · View at Scopus
  13. M. Chen, T. Masaki, and T. Sawamura, “LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis,” Pharmacology & Therapeutics, vol. 95, no. 1, pp. 89–100, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Meisinger, J. Baumert, N. Khuseyinova, H. Loewel, and W. Koenig, “Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population,” Circulation, vol. 112, no. 5, pp. 651–657, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Hutter, F. E. Carrick, C. Valdiviezo et al., “Vascular endothelial growth factor regulates reendothelialization and neointima formation in a mouse model of arterial injury,” Circulation, vol. 110, no. 16, pp. 2430–2435, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. S. H. van Ierssel, P. G. Jorens, E. M. Van Craenenbroeck, and V. M. Conraads, “The endothelium, a protagonist in the pathophysiology of critical illness: focus on cellular markers,” BioMed Research International, vol. 2014, Article ID 985813, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. J. George, E. Goldstein, S. Abashidze et al., “Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation,” European Heart Journal, vol. 25, no. 12, pp. 1003–1008, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. Q. Xu, “Progenitor cells in vascular repair,” Current Opinion in Lipidology, vol. 18, no. 5, pp. 534–539, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Imanishi, T. Hano, T. Sawamura, and I. Nishio, “Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction,” Clinical and Experimental Pharmacology and Physiology, vol. 31, no. 7, pp. 407–413, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. X. M. Feng, B. Zhou, Z. Chen et al., “Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase,” Journal of Lipid Research, vol. 47, no. 6, pp. 1227–1237, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Liu, Z.-Z. Liu, H. Chen, G.-J. Zhang, Y.-H. Kong, and X.-X. Kang, “Oxidized low-density lipoprotein and β-glycerophosphate synergistically induce endothelial progenitor cell ossification,” Acta Pharmacologica Sinica, vol. 32, no. 12, pp. 1491–1497, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Wu, Q. Wang, L. Cheng, J. Wang, and G. Lu, “Effect of oxidized low-density lipoprotein on survival and function of endothelial progenitor cell mediated by p38 signal pathway,” Journal of Cardiovascular Pharmacology, vol. 53, no. 2, pp. 151–156, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. S. di Santo, N. Diehm, J. Ortmann et al., “Oxidized low density lipoprotein impairs endothelial progenitor cell function by downregulation of E-selectin and integrin αvβ5,” Biochemical and Biophysical Research Communications, vol. 373, no. 4, pp. 528–532, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Ji, C. Xing, F. Jiang et al., “Benzo[a]pyrene induces oxidative stress and endothelial progenitor cell dysfunction via the activation of the NF-κB pathway,” International Journal of Molecular Medicine, vol. 31, no. 4, pp. 922–930, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. C.-P. Lin, F.-Y. Lin, P.-H. Huang et al., “Endothelial progenitor cell dysfunction in cardiovascular diseases: role of reactive oxygen species and inflammation,” BioMed Research International, vol. 2013, Article ID 845037, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. J. E. Deanfield, J. P. Halcox, and T. J. Rabelink, “Endothelial function and dysfunction: testing and clinical relevance,” Circulation, vol. 115, no. 10, pp. 1285–1295, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Perticone, R. Ceravolo, A. Pujia et al., “Prognostic significance of endothelial dysfunction in hypertensive patients,” Circulation, vol. 104, no. 2, pp. 191–196, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Werner, S. Kosiol, T. Schiegl et al., “Circulating endothelial progenitor cells and cardiovascular outcomes,” The New England Journal of Medicine, vol. 353, no. 10, pp. 999–1007, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Schmidt-Lucke, L. Rössig, S. Fichtlscherer et al., “Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair,” Circulation, vol. 111, no. 22, pp. 2981–2987, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Takahashi, C. Kalka, H. Masuda et al., “Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization,” Nature Medicine, vol. 5, no. 4, pp. 434–438, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Aicher, M. Rentsch, K.-I. Sasaki et al., “Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia,” Circulation Research, vol. 100, no. 4, pp. 581–589, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Cheng, R. Cui, C. H. Chen, and J. Du, “Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells,” Endocrinology, vol. 148, no. 5, pp. 2085–2094, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Tie, J. Yan, Y. Yang et al., “Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/akt pathway,” Journal of Vascular Research, vol. 47, no. 6, pp. 519–530, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Hamed, B. Brenner, and A. Roguin, “Nitric oxide: a key factor behind the dysfunctionality of endothelial progenitor cells in diabetes mellitus type-2,” Cardiovascular Research, vol. 91, no. 1, pp. 9–15, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Tie, K. E. Messina, J. Yan, J. A. Messina, and L. M. Messina, “Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells,” Journal of the American Heart Association, vol. 3, no. 1, Article ID e000241, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Meyer, R. Schreck, and P. A.baeuerle, “H2O2 and antioxidants have opposite effects on activation of NF-xχB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor,” The EMBO Journal, vol. 12, no. 5, pp. 2005–2015, 1993. View at Google Scholar · View at Scopus
  37. N. Li and M. Karin, “Is NF-κB the sensor of oxidative stress?” The FASEB Journal, vol. 13, no. 10, pp. 1137–1143, 1999. View at Google Scholar · View at Scopus
  38. J. Sugawara, M. Mitsui-Saito, C. Hayashi et al., “Decrease and senescence of endothelial progenitor cells in patients with preeclampsia,” The Journal of Clinical Endocrinology & Metabolism, vol. 90, no. 9, pp. 5329–5332, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Verma, M. A. Kuliszewski, S.-H. Li et al., “C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease,” Circulation, vol. 109, no. 17, pp. 2058–2067, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. W. Suh, K. L. Kim, J.-H. Choi et al., “C-reactive protein impairs angiogenic functions and decreases the secretion of arteriogenic chemo-cytokines in human endothelial progenitor cells,” Biochemical and Biophysical Research Communications, vol. 321, no. 1, pp. 65–71, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. F. H. Seeger, J. Haendeler, D. H. Walter et al., “p38 mitogen-activated protein kinase downregulates endothelial progenitor cells,” Circulation, vol. 111, no. 9, pp. 1184–1191, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. Y.-H. Chen, S.-J. Lin, F.-Y. Lin et al., “High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms,” Diabetes, vol. 56, no. 6, pp. 1559–1568, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. N. Werner and G. Nickenig, “Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy?” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 2, pp. 257–266, 2006. View at Publisher · View at Google Scholar · View at Scopus