Activity of α₁-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation

Table 2

Activity of lysosomal enzymes and -antitrypsin in the COPD patients who ceased smoking and in the representatives of the control groups: COPD patients who did not cease smoking and nonsmokers.

Group	Parameters
	AcP; (10^−2 nmol/mg of protein/min)	ASA; (10^−3 nmol/mg of protein/min)	CTS D; (10^−2 nmol/mg of protein/min)	AAT; (mg of trypsin/mL)
Control I (healthy nonsmokers)	1.45 ± 0.42	0.54 ± 0.13	1.65 ± 0.67	1.01 ± 0.17
COPD patients who did not cease smoking (control II)
At the start of the experiment	1.57 ± 0.66	0.6 ± 0.2	1.61 ± 0.62	1.82 ± 0.75
After the 1st month of the study	1.65 ± 0.75	0.57 ± 0.15	2.13 ± 0.61	1.83 ± 0.8
After the 2nd month of the study	1.79 ± 0.63	0.6 ± 0.17	1.93 ± 0.6	1.84 ± 0.68
After the 3rd month of the study	1.62 ± 0.47	0.59 ± 0.21	2.05 ± 1.0	1.88 ± 0.82
COPD patients who ceased smoking (study group)
Before smoking cessation	1.53 ± 0.66	0.57 ± 0.16	1.81 ± 0.78	1.84 ± 0.54
After the 1st month of tobacco abstinence	1.53 ± 0.71	0.55 ± 0.16	2.12 ± 0.56	1.84 ± 0.69
After the 2nd month of tobacco abstinence	1.89 ± 0.71	0.54 ± 0.19	1.97 ± 0.49	1.6 ± 0.59
After the 3rd month of tobacco abstinence	1.6 ± 0.6	0.59 ± 0.21	2.09 ± 0.88	1.64 ± 0.58

AcP: acid phosphatase; ASA: arylsulfatase; CTS D: cathepsin D; AAT: -antitrypsin.
Data expressed as mean   ± SD.
Statistically significant differences: versus control I: , < 0.001.