Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 178407, 13 pages
Review Article

Animal Models in Studying Cerebral Arteriovenous Malformation

1Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China
2Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China

Received 6 August 2015; Revised 11 October 2015; Accepted 25 October 2015

Academic Editor: Aaron S. Dumont

Copyright © 2015 Ming Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Brain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke. The etiology is largely unknown and the therapeutics are controversial. A review of AVM-associated animal models may be helpful in order to understand the up-to-date knowledge and promote further research about the disease. We searched PubMed till December 31, 2014, with the term “arteriovenous malformation,” limiting results to animals and English language. Publications that described creations of AVM animal models or investigated AVM-related mechanisms and treatments using these models were reviewed. More than 100 articles fulfilling our inclusion criteria were identified, and from them eight different types of the original models were summarized. The backgrounds and procedures of these models, their applications, and research findings were demonstrated. Animal models are useful in studying the pathogenesis of AVM formation, growth, and rupture, as well as in developing and testing new treatments. Creations of preferable models are expected.