Early Fluid Resuscitation and High Volume Hemofiltration Decrease Septic Shock Progression in Swine
Table 3
Levels of serum inflammatory mediators.
Variable/group
Baseline
Upon successful resuscitation
1 h
2 h
3 h
4 h
5 h
6 h
IL-6 (pg/mL)
Control
96 (75; 125)
475 (449; 549)
604 (533; 633)
627 (602; 668)
699 (663; 721)
734 (718; 750)
826 (785; 841)
785 (775; 848)
CRRT
99 (87; 152)
525 (475; 575)
403.5 (387; 434)
400 (387; 424)
479 (460; 517)
465 (425; 495)
501 (454; 540)
493 (482; 536)
HVHF
129 (92; 155)
507 (472; 559)
408.5 (390; 438)
422 (404; 424)
447.5 (411; 506)
403 (394; 411)
394 (344; 421)
364 (294; 380)
0.330
0.581
0.003
0.003
0.004
0.001
0.001
0.001
IL-10 (pg/mL)
Control
14 (11; 14)
68 (60; 78)
76 (72; 82)
91 (86; 97)
97 (91; 104)
98 (97; 106)
112 (101; 119)
106 (100; 127)
CRRT
16 (8; 18)
61 (56; 75)
67 (64; 74)
51 (49; 52)
50 (48; 55)
45 (42; 46)
41 (34; 46)
37 (31; 39)
HVHF
15 (12; 17)
75 (66; 80)
51 (46; 56)
41 (38; 48)
40 (34; 44)
31 (28; 33)
31 (27; 34)
27 (25; 30)
0.431
0.277
0.003
0.001
0.001
0.001
0.002
0.001
CRRT: continuous renal replacement therapy; HVHF: high volume hemofiltration. between the CRRT and control groups, between the HVHF and control groups, between the CRRT and HVHF groups.
