Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study

Table 1

Characteristics of patients with MPMs.

Patient	Sex	Year of kidney transplant	Patient’s age at transplant	Immunosuppressive drugs used	Acute rejection events	Type of first tumor	Date of first tumor	Type of second tumor	Date of second tumor	Return to dialysis (year)	Status; (last follow-up)
1	M	1995	39	CCS + CyA + Myc	No	BCC	2001	Melanoma	2006	No	Alive (2012)
2	M	1987	25	CCS + CyA	No	SCC	2008	SCC	2008	Yes (2010)	Alive (2012)
3	M	2001	64	CCS + CyA + Myc	No	BCC	2006	SCC	2006	Yes (2011)	Alive (2012)
4	M	2003	62	CCS + FK >; > Rap + CCS	No	Prostate Ca	2010	Kidney Ca	2010	No	Alive (2012)
5	M	2001	55	CCS + CyA + Myc	No	BCC	2002	SCC	2002	No	Alive (2010)
6	M	1988	45	CyA > Rap + CCS	No	Kaposi	2004	Gastric MALToma	2005	Yes (2006)	Dead (2006)
7	M	2001	55	CCS + FK + Myc	No	BCC	2003	SCC	2003	No	Alive (2012)
8	M	1992	42	CCS + CyA	No	SCC	2005	BCC + SCC	2005	No	Alive (2012)
9	M	1997	39	CyA + Aza	No	SCC	2003	Melanoma	2012	No	Alive (2012)
10	M	1995	51	CCS + CyA + Myc	No	BCC	2005	BCC + SCC	2010/2011	No	Alive (2012)
11	F	2004	53	CCS + CyA >; > Rap + CCS	No	Lung Ca	2005	SCC	2006	Yes (2007)	Dead (2007)
12	M	1998	56	CCS + CyA	No	SCC	1999	BCC	2007	No	Alive (2012)
13	M	1992	18	CCS + CyA + Myc	Yes	BCC	2000	SCC	2000	Yes (2008)	Alive (2012)
14	M	2001	61	CCS + Rap + Myc	No	SCC	2006	SCC	2007	No	Alive (2007)
15	M	1989	29	CyA + Aza >; > Rap + CCS	No	BCC	2007	SCC	2007	No	Alive (2012)
16	M	2005	43	CCS + CyA	No	Melanoma	2008	BCC	2008	No	Alive (2012)
17	M	1999	59	CCS + CyA + Myc	No	BCC	2004	SCC	2004	No	Alive (2011)
18	M	1986	46	CCS + CyA	No	SCC	1997	Melanoma	2004	Yes (2004)	Dead (2007)
19	M	2000	35	CCS + CyA + Myc	No	SCC	2006	BCC	2012	No	Alive (2012)
20	M	1994	38	CCS + CYA	No	SCC	2000	SCC	2000	Yes (2010)	Alive (2012)
21	F	1999	56	CCS + CYA	No	SCC	2004	BCC	2004	No	Alive (2012)
22	F	1996	49	FK + Aza >; > FK	No	BCC	2001	BCC	2001	No	Alive (2012)
23	F	1987	56	CCS + FK	No	BCC	1998	SCC	2006	Yes (2011)	Alive (2012)
24	M	2005	60	CCS + FK >; > Rap > FK	No	SCC	2006	Colon Ca	2011	Yes (2012)	Alive (2012)

M: male; F: female.
CCS: corticosteroids; Aza: azathioprine; CyA: cyclosporine; FK: tacrolimus; Myc: mycophenolate and derivatives; Rap: rapamycin and derivatives.
>: switch to other drug(s).
Ca: carcinoma; SCC: squamous cell carcinoma; BCC: basal cell carcinoma; Kaposi: Kaposi sarcoma; MALToma: neoplasm of mucosa associated lymphoid tissue.