Research Article
Biomarker Identification and Pathway Analysis by Serum Metabolomics of Lung Cancer
Table 6
ROC curves of potential serum biomarker levels for differentiating the control group from the PRLC group.
| Marker | Cutoff value | Sensitivity (%) | Specificity (%) | AUC | p value* | 95% CIa |
| Prasterone sulfate | 91.07 | 76.67 | 80.00 | 0.787 | <0.001 | 0.670–0.905 | Sphingosine | 102.76 | 90.00 | 96.67 | 0.957 | <0.001 | 0.894–1.019 | Serine | 113.21 | 83.33 | 73.33 | 0.774 | <0.001 | 0.645–0.904 | 2,3,4-Trihydroxybutyric acid | 45.87 | 86.67 | 83.33 | 0.880 | <0.001 | 0.794–0.966 |
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*Asymptotic significance, null hypothesis: true area = 0.5. a95% confidence interval of the difference.
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