Biomarker Identification and Pathway Analysis by Serum Metabolomics of Lung Cancer

Table 7

ROC curves of potential serum biomarker levels for differentiating the POLC group from the PRLC group.

Marker	Cutoff value	Sensitivity (%)	Specificity (%)	AUC	p value^*	95% CI^a
Phosphorylcholine	84.69	76.67	70.00	0.781	<0.001	0.666–0.896
Glycerophospho-N-arachidonoyl ethanolamine	1988.46	76.67	93.33	0.916	<0.001	0.847–0.984
-Linolenic acid	808.24	76.67	90.00	0.847	<0.001	0.744–0.949
9,12-Octadecadienoic acid	21.29	53.33	86.67	0.645	<0.001	0.499–0.791
Oleic acid	489.02	60.00	80.00	0.694	<0.001	0.550–0.838
CEA	2.90	70.00	83.33	0.772	<0.001	0.646–0.898
CYFRA21-1	1.64	70.00	70.00	0.737	<0.001	0.646–0.863

 ^*Asymptotic significance, null hypothesis: true area = 0.5.
^a95% confidence interval of the difference.