Research Article
Biomarker Identification and Pathway Analysis by Serum Metabolomics of Lung Cancer
Table 7
ROC curves of potential serum biomarker levels for differentiating the POLC group from the PRLC group.
| Marker | Cutoff value | Sensitivity (%) | Specificity (%) | AUC | p value* | 95% CIa |
| Phosphorylcholine | 84.69 | 76.67 | 70.00 | 0.781 | <0.001 | 0.666–0.896 | Glycerophospho-N-arachidonoyl ethanolamine | 1988.46 | 76.67 | 93.33 | 0.916 | <0.001 | 0.847–0.984 | -Linolenic acid | 808.24 | 76.67 | 90.00 | 0.847 | <0.001 | 0.744–0.949 | 9,12-Octadecadienoic acid | 21.29 | 53.33 | 86.67 | 0.645 | <0.001 | 0.499–0.791 | Oleic acid | 489.02 | 60.00 | 80.00 | 0.694 | <0.001 | 0.550–0.838 | CEA | 2.90 | 70.00 | 83.33 | 0.772 | <0.001 | 0.646–0.898 | CYFRA21-1 | 1.64 | 70.00 | 70.00 | 0.737 | <0.001 | 0.646–0.863 |
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*Asymptotic significance, null hypothesis: true area = 0.5. a95% confidence interval of the difference.
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