Review Article

T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-Antitrypsin

Figure 2

T helper (TH) cells differentiation and reprograming. TH0 cell can differentiate into specific TH subsets (gray arrows) under the influence of cytokines, which on the one hand can promote differentiation into a specific subset (green arrows) and on the other hand block differentiation towards a functionally-opposing subset (red blocked arrows). In addition, differentiated TH cells may be reprogramed to acquire a different TH phenotype (black arrows).