BioMed Research International / 2015 / Article / Tab 1

Research Article

Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma

Table 1

Clinicopathologic sample characteristics and MT1-MMP expression.

Number of patients79

m/f45/34

Age (yrs, median/range/IQR)75/25–92/15

Tumor localization (right/left colon/unknown)27/48/4

MT1-MMP expressionMT1-MMP−MT1-MMP+P

Histopathological grading ()
 Low-grade15161.0
 High-grade2124

UICC stage ()
 I11160.8934
 II107
 III1114
 IV45

T stage ()
 T1/212160.633
 T3/42423

N stage ()
 N020211.0
 N1/21416

KRAS mutation status ()
KRASwt24250.812
KRASmut11215

BRAF mutation status ()
BRAFwt32351.0
BRAFmut245

MMR protein expression ()
 MMR proteins expressed32280.471
 Loss of MMR protein expression335

Presence of lymphovascular invasion ()
 L0V014210.336
 L1/V11513
 L1V185

Tumor cell budding ()
 Low-grade26310.609
 High-grade109

Growth pattern ()
 Expanding24230.641
 infiltrating1317

Tumor-infiltrating lymphocytes (TILs; )
 Absent24251.0
 Present1315

1KRAS G12D, G12V, G12C, G12S, and G12R; G13D; Q61K; Q61L; 2BRAF V600E; 3MLH-1, MSH-2, MSH-6, and PMS-2; 4Chi-Square test for trend.

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