BioMed Research International / 2015 / Article / Tab 1

Review Article

MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis

Table 1

Summary of miRNAs and associated signal pathways/target genes in OSCC/HNSCC.

miRNAUp/downregulationTarget genes/associated pathwaysRef.

miR-21UpPDCD4[23]
TPMI[16]
RECK[26]
CLU[22]
DKK2-Wnt/β-catenin[18]
Smad7-TGFβ1[27]
HA/CD44-Nanog/Stat3-PDCD4, IAPs[24]

miR-31UpFIH-HIF-EVGF[28]

miR-31UpFGF3[29]
RhoA[32]

miR-134UpWWOX[36]

miR-146aUpIRK1, TRAF6, and NUMB[33]

miR-155UpCDC73[39]

miR-7UpRECK[26]
IGF1R-Akt[45]

miR-9DownCXCR4-Wnt/β-catenin[50]

miR-17/20aDownITGβ8[60]

miR-29aDownMMP2[57]

miR-34DownE2F3, survivin, and VEGF[64]
SIRT6[89]

miR-99aDownIGF1R[46]

miR-124DownITGB1[58]

miR-125bDownICAM2[65]

miR-138DownFOSL1[52]
VIM, ZEB2, EZH2[53]
RhoC, and RoCK2[54]

miR-140-5pDownADAM10, ERBB4, PAX6, and LAMC1[90]

miR-145Downc-Myc, Cdk6[67]

miR-181aDownK-ras[91]
Twist1[56]

miR-205DownIL-24, caspase-3/-7,[92]
and Axin-2[93]

miR-218DownmTOR-Rictor-Akt[48]

miR-320DownHIF-1α-NRP1-VEGF[41]

miR-357DownCIP2A-MYC[61]
AEG-1/MTDH[62]

miR-419-5pDownGIT1[59]
EGFR-ERK1/2-MMP2/9

miR-483-3pAPI5, BRIC5, and RAN[94]

miR-196aUpMAMDC2[95]

miR-26a/bDownTMEM184B[96]