BioMed Research International / 2015 / Article / Tab 2 / Review Article
MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis Table 2 miRNA deregulation and relevance to OSCC diagnosis and prognosis.
miRNA(s) Source Up/downregulation (OSCC versus normal control) Diagnostic/prognostic relevance Ref. miR-16, Let-7b Serum Up Yes/ND [69 ]a miR-223, miR-29a, Serum Down and miR-338-3p miR-24 Plasma Up Yes/ND [70 ] miR-146a Tissue/plasma Up Yes/ND [33 ] miR-21 Tissue Up Yes/ND [71 ]b Plasma Up Yes/yes Tissue Up ND/yes [16 ]c Tissue Up ND/yes [26 ] Tissue Up Yes/yes [17 , 80 ]b Tissue Up ND/yes [20 ]d miR-31 Saliva Up Yes/ND [72 ] miR-27b Saliva Up Yes/ND [73 ] miR-125b Tissue Down ND/yes [65 ] miR-491-5p Tissue Down ND/yes [59 ] miR-181 Plasma/tissue Up Yes/yes [77 ] miR-375 Tissue Down ND/yes [78 ]b miR-205 and Let-7d Tissue Down ND/yes [79 ]b miR-155 Tissue Up ND/yes [38 ] Tissue Up Yes/yes [37 ] miR-21-3p Tissue Up ND/yes [97 ] miR-141-3p miR-96-5p miR-130b-3p miR-196a/b Tissue Up Yes/yes [98 ] miR-196a Plasma Up Yes/yes miR-211 Tissue Down ND/yes [99 ]
a OSCC group also consists of lesions with carcinoma in situ ; b HNSCC specimens; c TSCC; d expression examined in the tumor stroma; Ref.: references; ND: not determined.