BioMed Research International / 2015 / Article / Tab 2

Review Article

MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis

Table 2

miRNA deregulation and relevance to OSCC diagnosis and prognosis.

miRNA(s)SourceUp/downregulation (OSCC versus normal control)Diagnostic/prognostic relevanceRef.

miR-16, Let-7bSerumUpYes/ND[69]a
miR-223, miR-29a,SerumDown
and miR-338-3p

miR-24PlasmaUpYes/ND[70]

miR-146aTissue/plasmaUpYes/ND[33]

miR-21TissueUpYes/ND[71]b
PlasmaUpYes/yes
TissueUpND/yes[16]c
TissueUpND/yes[26]
TissueUpYes/yes[17, 80]b
TissueUpND/yes[20]d

miR-31SalivaUpYes/ND[72]

miR-27bSalivaUpYes/ND[73]

miR-125bTissueDownND/yes[65]

miR-491-5pTissueDownND/yes[59]

miR-181Plasma/tissueUpYes/yes[77]

miR-375TissueDownND/yes[78]b

miR-205 and Let-7dTissueDownND/yes[79]b

miR-155TissueUpND/yes[38]
TissueUpYes/yes[37]

miR-21-3pTissueUpND/yes[97]
miR-141-3p
miR-96-5p
miR-130b-3p

miR-196a/bTissueUpYes/yes[98]
miR-196aPlasmaUpYes/yes

miR-211TissueDownND/yes[99]

aOSCC group also consists of lesions with carcinoma in situ; bHNSCC specimens; cTSCC; dexpression examined in the tumor stroma; Ref.: references; ND: not determined.