Lower Urinary Tract Symptoms Are Associated with Increased Risk of Dementia among the Elderly: A Nationwide Study

Table 2

Incidence of dementia in LUTS patients.

	Non-LUTS ()				LUTS ()				Adjusted IRR^* (95% CI)
		Dementia number	PY	IR		Dementia number	PY	IR
Total	20403	1418	182760.38	77.59	6801	741	59392.21	124.76	1.63 (1.49–1.78)	<0.0001
Age (years)
50~60	5171	67	47695.02	14.05	1723	36	15834.09	22.74	1.62 (1.08–2.43)	0.0198
60~70	6491	284	59208.05	47.97	2164	185	19289.33	95.91	2.00 (1.66–2.41)	<0.0001
70~80	7071	804	61574.10	130.57	2356	396	19740.50	200.60	1.54 (1.37–1.74)	<0.0001
≥80	1670	263	14283.21	184.13	558	124	4528.29	273.83	1.49 (1.20–1.84)	<0.0003
Gender
Male	11469	814	101731.17	80.02	3823	403	33165.82	121.51	1.52 (1.36–1.72)	<0.0001
Female	8934	604	81029.20	74.54	2978	338	26226.39	128.88	1.76 (1.54–2.01)	<0.0001
Hypertension
No	13454	809	121784.75	66.43	4381	393	39480.85	99.54	1.49 (1.32–1.69)	<0.0001
Yes	6949	609	60975.62	99.88	2420	348	19911.36	174.78	1.81 (1.59–2.06)	<0.0001
Diabetes
No	17418	1156	156414.36	73.91	5660	585	49944.80	117.13	1.62 (1.47–1.79)	<0.0001
Yes	2985	262	26346.02	99.45	1141	156	9447.41	165.13	1.62 (1.33–1.98)	<0.0001
Coronary artery disease
No	17995	1180	161652.69	73.00	5894	614	51908.31	118.29	1.66 (1.50–1.83)	<0.0001
Yes	2408	238	21107.69	112.76	907	127	7483.90	169.70	1.48 (1.19–1.84)	0.0004
Hyperlipidemia
No	18827	1311	169048.45	77.55	6227	665	54693.83	121.59	1.58 (1.44–1.74)	<0.0001
Yes	1576	107	13711.93	78.03	574	76	4698.38	161.76	2.16 (1.61–2.91)	<0.0001
Cerebrovascular disease
No	18812	1220	169158.45	72.12	6094	607	53732.30	112.97	1.59 (1.45–1.76)	<0.0001
Yes	1591	198	13601.92	145.57	707	134	5659.92	236.75	1.66 (1.33–2.07)	<0.0001
Atrial fibrillation
No	20174	1395	180772.73	77.17	6700	719	58568.11	122.76	1.61 (1.47–1.76)	<0.0001
Yes	229	23	1987.65	115.72	101	22	824.10	266.96	2.27 (1.26–4.06)	0.0061

CI: confidence interval; IR: incidence rate, per 1000 person-years; IRR: incidence rate ratio; LUTS: lower urinary tract symptoms; PY: person-years.
^*The IRR was adjusted by age and gender.