Current and Potential Applications of Host-Defense Peptides and Proteins in Urology

Table 1

Summary of host-defense peptides discussed.

Peptide name/inducers	Peptide sequence	Current/potential application in urology	References
Lactoferrin-derived peptide HLD1	EATKCFQWQRNMRKVRGPPVSCIKR-NH2	Oral administration for UTI	[17]
Lactoferrin-derived peptide HLD2	TK©FQWQRNMRKVRGPPVS©IKR-NH2
Tachyplesin III	KWCFRVCYRGICYRKCR-NH2	Antimicrobial coating for urologic devices	[7]
Tet-20	KRWRIRVRVIRKC-NH2		[18]
RK1 (salt-tolerant)	RWKRWWRRKK		[19]
RK2 (salt-tolerant)	RKKRWWRRKK		[19]
Magainin II	GIGKFLHSAKKFGKAFVGEIMNS-NH2	Target bladder cancer cells	[20–22]
Cecropin A	KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK-NH2		[23]
Cecropin B	KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL-NH2
Peptoids	Most potent one analyzed: H-(Nlys-Nspe-Nspe)4-NH2		[24]
Human -defensin-1	DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK-NH2		[25–27]
OPN-derived peptides	Many OPN-derived peptides were analyzed; one of the more promising ones being OPN-derived peptide D9: ADAAADDAAADAAADDAA-NH2	Target kidney stones	[28]