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BioMed Research International
Volume 2015, Article ID 189190, 9 pages
http://dx.doi.org/10.1155/2015/189190
Research Article

Unsaturated Fatty Acids Supplementation Reduces Blood Lead Level in Rats

1Department of Internal and Occupational Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland
2Department of Human Nutrition, Wroclaw University of Environmental and Life Sciences, 51-630 Wrocław, Poland
3Department of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, 51-630 Wrocław, Poland

Received 1 December 2014; Accepted 27 April 2015

Academic Editor: Brad Upham

Copyright © 2015 Anna Skoczyńska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Some dietary factors could inhibit lead toxicity. The aim of this study was to evaluate the effect of dietary compounds rich in unsaturated fatty acids (FA) on blood lead level, lipid metabolism, and vascular reactivity in rats. Serum metallothionein and organs’ lead level were evaluated with the aim of assessing the possible mechanism of unsaturated FA impact on blood lead level. For three months, male Wistar rats that were receiving drinking water with (100 ppm Pb) or without lead acetate were supplemented per os daily with virgin olive oil or linseed oil (0.2 mL/kg b.w.) or egg derived lecithin fraction: “super lecithin” (50 g/kg b.w.). Mesenteric artery was stimulated ex vivo by norepinephrine (NE) administered at six different doses. Lecithin supplementation slightly reduced pressor responses of artery to NE. Lead administered to rats attenuated the beneficial effect of unsaturated FA on lipid metabolism and vascular reactivity to adrenergic stimulation. On the other hand, the super lecithin and linseed oil that were characterized by low omega-6 to omega-3 ratio (about 1) reduced the blood lead concentration. This effect was observed in lead poisoned rats and also in rats nonpoisoned with lead .