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BioMed Research International
Volume 2015, Article ID 191489, 4 pages
Research Article

Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not?

1Department of General Internal Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan
2Division of Molecular and Cell Biology, Kanazawa Medical University, Ishikawa 920-0293, Japan

Received 1 December 2014; Revised 26 April 2015; Accepted 13 May 2015

Academic Editor: Anjali Joshi

Copyright © 2015 Junji Moriya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To investigate whether Brucella abortus (BA) antigen injections lead to anemia, and to establish an appropriate Chronic Fatigue Syndrome (CFS) animal model by BA injections, 6 repeated injections of BA antigen were fulfilled every 2 weeks. At a high dose of particles/mouse, anemia was induced within 2 weeks and then recovered a lot at the end of the research, while at a moderate dose of (3 injections) shifting to /mouse (3 injections) anemia was absent. In both groups running wheel activity remained very low even 6 weeks after the last injection.