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BioMed Research International
Volume 2015, Article ID 191489, 4 pages
http://dx.doi.org/10.1155/2015/191489
Research Article

Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not?

1Department of General Internal Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan
2Division of Molecular and Cell Biology, Kanazawa Medical University, Ishikawa 920-0293, Japan

Received 1 December 2014; Revised 26 April 2015; Accepted 13 May 2015

Academic Editor: Anjali Joshi

Copyright © 2015 Junji Moriya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Fukuda, S. E. Straus, I. Hickie, M. C. Sharpe, J. G. Dobbins, and A. Komaroff, “The chronic fatigue syndrome: a comprehensive approach to its definition and study,” Annals of Internal Medicine, vol. 121, no. 12, pp. 953–959, 1994. View at Publisher · View at Google Scholar · View at Scopus
  2. W. C. Reeves, A. Lloyd, S. D. Vernon et al., “Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution,” BMC Health Services Research, vol. 3, article 1, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Skowera, A. Cleare, D. Blair, L. Bevis, S. C. Wessely, and M. Peakman, “High levels of type 2 cytokine-producing cells in chronic fatigue syndrome,” Clinical and Experimental Immunology, vol. 135, no. 2, pp. 294–302, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. B. H. Natelson, M. H. Haghighi, and N. M. Ponzio, “Evidence for the presence of immune dysfunction in chronic fatigue syndrome,” Clinical and Diagnostic Laboratory Immunology, vol. 9, no. 4, pp. 747–752, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Carlo-Stella, C. Badulli, A. de Silvestri et al., “A first study of cytokine genomic polymorphisms in CFS: positive association of TNF-857 and IFNγ874 rare alleles,” Clinical and Experimental Rheumatology, vol. 24, no. 2, pp. 179–182, 2006. View at Google Scholar · View at Scopus
  6. R. Perricone, C. Perricone, C. De Carolis, and Y. Shoenfeld, “NK cells in autoimmunity: a two-edg'd weapon of the immune system,” Autoimmunity Reviews, vol. 7, no. 5, pp. 384–390, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. M. J. Robertson, R. S. Schacterle, G. A. Mackin et al., “Lymphocyte subset differences in patients with chronic fatigue syndrome, multiple sclerosis and major depression,” Clinical and Experimental Immunology, vol. 141, no. 2, pp. 326–332, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. Harrington, “Neurobiological studies of fatigue,” Progress in Neurobiology, vol. 99, no. 2, pp. 93–105, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. J. E. Ottenweller, B. H. Natelson, W. C. Gause et al., “Mouse running activity is lowered by Brucella abortus treatment: a potential model to study chronic fatigue,” Physiology & Behavior, vol. 63, no. 5, pp. 795–801, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Chen, J. Moriya, J.-I. Yamakawa et al., “Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41),” Neurochemical Research, vol. 33, no. 9, pp. 1759–1767, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Moriya, R. Chen, J.-I. Yamakawa, K. Sasaki, Y. Ishigaki, and T. Takahashi, “Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells,” Biological & Pharmaceutical Bulletin, vol. 34, no. 3, pp. 354–359, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. B. J. Sasu, K. S. Cooke, T. L. Arvedson et al., “Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia,” Blood, vol. 115, no. 17, pp. 3616–3624, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Gardenghi, T. M. Renaud, A. Meloni et al., “Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus,” Blood, vol. 123, no. 8, pp. 1137–1145, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Kim, E. Fung, S. G. Parikh et al., “A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin,” Blood, vol. 123, no. 8, pp. 1129–1136, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Gupta, G. Vij, S. Sharma, N. Tirkey, P. Rishi, and K. Chopra, “Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model,” Immunobiology, vol. 214, no. 1, pp. 33–39, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Chen, J. Moriya, X. Luo et al., “Hochu-ekki-to combined with interferon-gamma moderately enhances daily activity of chronic fatigue syndrome mice by increasing NK cell activity, but not neuroprotection,” Immunopharmacology and Immunotoxicology, vol. 31, no. 2, pp. 238–245, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Vij, A. Gupta, and K. Chopra, “Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant,” Fundamental and Clinical Pharmacology, vol. 23, no. 3, pp. 331–337, 2009. View at Publisher · View at Google Scholar · View at Scopus