Research Progress on the Role of ABC Transporters in the Drug Resistance Mechanism of Intractable Epilepsy
mdr1 mRNA levels in the hippocampus and entorhinal cortex of rats with spontaneous seizures. Data are the means ± SE () of the optical density values of gel bands representing the PCR amplification products of mdr1 mRNA normalized to the corresponding β-actin band used in each sample as an internal standard. Values in spontaneously epileptic rats (SE) are expressed as a percentage of the control levels (sham-stimulated rats (Sham)). HP, stimulated hippocampus (1.8-fold increase); EC, contralateral entorhinal cortex (5.5-fold increase). versus sham according to a Mann-Whitney test.