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BioMed Research International
Volume 2015, Article ID 196495, 6 pages
Review Article

Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head

1Department of Orthopaedics, Chinese People’s Liberation Army General Hospital, 301 Orthopaedic Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China
2Cancer Center, Division of Internal Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, 28 Fuxing Road, Haidian District, Beijing 100853, China
3Medical School of Nankai University, 94 Weijin Road, Tianjin 300071, China
4Department of Orthopaedics, University of Chicago Hospital, 5841 S. Maryland Avenue, Chicago, IL 60637, USA

Received 3 July 2014; Accepted 24 September 2014

Academic Editor: Dongquan Shi

Copyright © 2015 Wei Chai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Methylenetetrahydrofolate reductase (MTHFR) SNP rs1801133 has been frequently investigated in recent years. Relevant candidate gene association studies with this SNP and osteonecrosis of the femoral head (ONFH) reported conflicting results. Meta-analysis provides a method to combine these data and to determine the association in a larger sample size. Method. We conducted a systematic search to identify possible studies. Four pooled ORs (odds ratios, T versus C, TT versus CC, TT/CT versus CC, and TT versus CT/CC), along with 95% confidence interval (CI), were calculated to evaluate the association between SNP rs1801133 and ONFH susceptibility. Both fixed effects model and random effects model were used. Findings. We eventually included twelve studies in this analysis, with results showing no overall association between ONFH susceptibility and SNP rs1801133 (T versus C: , 95% –1.38; TT versus CC: , 95% –1.46; TT/CT versus CC: , 95% –1.25; and TT versus CT/CC: , 95% –1.45). When stratified based on ethnicity, the results were still not significant. Conclusion. Our findings are generally supportive of no association between MTHFR SNP rs1801133 and the etiology of ONFH.