Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head

Table 2

Meta-analysis of the association between MTHFR SNP rs1801133 and ONFH risk.

Contrast model	Studies	Odds ratio		Model	Heterogeneity
		OR (95% CI)	OR
Total studies	12
T versus C	11	1.15 (0.97, 1.38)	0.095	Random	0.027
TT versus CC	11	1.15 (0.91, 1.46)	0.227	Fixed	0.234
TT/CT versus CC	12	1.09 (0.95, 1.25)	0.222	Fixed	0.245
TT versus CT/CC	11	1.16 (0.93, 1.45)	0.178	Fixed	0.188
Caucasians	7
T versus C	6	1.12 (0.82, 1.53)	0.428	Random	0.073
TT versus CC	6	0.99 (0.62, 1.61)	0.983	Fixed	0.336
TT/CT versus CC	7	1.13 (0.90, 1.41)	0.295	Fixed	0.208
TT versus CT/CC	6	0.93 (0.59, 1.46)	0.742	Fixed	0.258
Asians	5
T versus C	5	1.19 (0.93, 1.51)	0.138	Random	0.037
TT versus CC	5	1.21 (0.92, 1.58)	0.164	Fixed	0.141
TT/CT versus CC	5	1.07 (0.90, 1.27)	0.460	Fixed	0.271
TT versus CT/CC	5	1.25 (0.97, 1.60)	0.086	Fixed	0.161

OR: odds ratio, 95% CI: 95% confidence interval, Random: random effects model, Fixed: fixed effects model.