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BioMed Research International
Volume 2015, Article ID 197270, 5 pages
Research Article

Computer-Simulated Biopsy Marking System for Endoscopic Surveillance of Gastric Lesions: A Pilot Study

1Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China
2Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China
3College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China
4Key Laboratory of Biomedical Engineering, Ministry of Education, Zhejiang University, Hangzhou 310027, China
5Division of Gastroenterology, Loma Linda University, Loma Linda, CA 92354, USA

Received 19 June 2014; Revised 11 August 2014; Accepted 15 August 2014

Academic Editor: Tao Huang

Copyright © 2015 Weiling Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Endoscopic tattoo with India ink injection for surveillance of premalignant gastric lesions is technically cumbersome and may not be durable. The aim of the study is to evaluate the accuracy of a novel, computer-simulated biopsy marking system (CSBMS) developed for the endoscopic marking of gastric lesions. Twenty-five patients with history of gastric intestinal metaplasia received both CSBMS-guided marking and India ink injection in five points in the stomach at index endoscopy. A second endoscopy was performed at three months. Primary outcome was accuracy of CSBMS (distance between CSBMS probe-guided site and tattoo site measured by CSBMS). The mean accuracy of CSBMS at angularis was  mm, antral lesser curvature  mm, antral greater curvature  mm, antral anterior wall  mm, and antral posterior wall  mm. CSBMS ( versus seconds; ) required less procedure time compared to endoscopic tattooing. No adverse events were encountered. CSBMS accurately identified previously marked gastric sites by endoscopic tattooing within 1 cm on follow-up endoscopy.