Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome

Figure 1

Validation of the mathematical model of Brugada syndrome (BrS). (a) Ventricular epicardial action potentials (APs). Top row shows simulated normal and BrS types 1 and 2 human epicardial models, with delayed dome (solid) and lost dome (dashed) in the latter. Bottom row shows experimental AP recordings (healthy human epicardial AP, adapted from [33], microelectrode recordings in a male dog using 5 μM terfenadine, data courtesy of J. Fish and C. Antzelevitch, and in vivo human BrS epicardial monophasic APs, adapted from [24], resp.). (b) Reconstructed transmural pseudo-ECGs under normal and BrS conditions, together with epicardial (solid), endocardial (dashed), and midmyocardial (dash-dotted) APs. To obtain the two different morphologies of ST-segment elevation, Model 1 was used with for the saddleback type and with and for the coved type.

(a)

(b)