Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome

Figure 5

Induction of reentrant activity by phase-2 reentry (P2R) in the right ventricular free wall. Under endocardial stimulation, the Brugada epicardial delayed-dome region is able to initiate P2R in the lost-dome region (ms). The P2R wavefront propagates from apex to base (ms), where it reexcites the recovered endocardial layer (ms). Afterwards, reentry develops transmurally ( ms). Epicardial and endocardial views of the right ventricular free wall are provided. Color bar denotes transmembrane potential. Epicardial regions are as follows: lost-dome Brugada, upper left; late-dome Brugada, lower left; and normal, right.