Genome-Wide Methylome Analyses Reveal Novel Epigenetic Regulation Patterns in Schizophrenia and Bipolar Disorder

Figure 2

Genomic distribution of DMRs in schizophrenia (SZ). (a) The number of differentially methylated regions was counted for each SZ sample. The red bar indicates hypermethylated DMRs and the green bar indicates hypomethylated DMRs. (b) The cumulative distribution of lengths of DMRs for hyper- or hypomethylated DMRs. Red lines indicate hypermethylated and green lines hypomethylated DMRs. (c) Pie chart representing the proportions of DMRs in SZ samples. The darker the color shade, the greater the number of samples. A segment is regarded as differentially methylated if the overlap length was larger than 250 bp. (d) Chromosome band enrichment of ultra DMRs. Red stars indicate hypermethylated chromosome bands and green circles indicate hypomethylated bands. The bands indicated in the upper right panel show FDR less than 0.01 and odds ratios greater than one.

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