Epigenomics of Neural Cells: REST-Induced Down- and Upregulation of Gene Expression in a Two-Clone PC12 Cell Model

<div>Phenotypic pathways of the ChIP-Seq enriched, upregulated genes of hrPC12 cells. (a) shows pathways of possible REST target genes: 1–3: focal adhesion; 4 and 5: PG synthesis; 6: extracellular matrix. (b) shows pathways of possible REST nontarget genes. 1–3: extracellular matrix organization. 4: receptor interaction; 5: focal adhesion; 6: muscle structure/function; 7–10: enzymes and metabolism.</div>

BioMed Research International

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Figure 3: Epigenomics of Neural Cells: REST-Induced Down- and Upregulation of Gene Expression in a Two-Clone PC12 Cell Model 