Research Article
A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats
Figure 3
WM130 inhibited the migration and invasion of HSC-T6 cells. (a) The migration ability of HSC-T6 cells was analyzed by a scratch motility assay. WM130 68 μM group revealed a less migration distance during the treatment period of 0–48 h, compared with the control group or M19 group. (b) The effect of WM130 on inhibiting invasion of HSC-T6 cells was examined by transwell chamber assay. Invasive ability of HSC-T6 cells was quantified by counting the number of stained cells under microscopy (at 200x magnification). , versus Control group; ## versus M19 68 μM group.
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