Biphasic Regulation of Lipid Metabolism: A Meta-Analysis of Icodextrin in Peritoneal Dialysis

Table 1

Characteristics of RCTs and cross-sectional studies included in the meta-analysis.

Study	Year	Country	Study type	Sample size	Modality	Intervention duration (months)	Solution type	Number	Mean age (yr)	Gender (M/F)	Study quality (Jadad)
Sniderman et al. [15]	2014	Canada	RCT	251	CAPD/APD	⁢6	ICO	124	57 ± 12	64/60	4
							GLU	127	58 ± 13	59/68
Takatori et al. [16]	2011	Japan	RCT	41	N.A.	⁢24	ICO	21	55.90 ± 11.16	14/7	3
							GLU	20	56.50 ± 9.86	13/7
Kanda et al. [17]	2013	Japan	Cross-sectional	49	CAPD/APD	⁢N.A.	ICO	26	63.5 ± 11.4	19/7	N.A.
							GLU	23	64.9 ± 12.5	19/4
Kanbay et al. [18]	2007	Turkey	Cross-sectional	67	CAPD	⁢≥6	ICO	31	49 ± 16.1	17/14	N.A.
							GLU	18	40.8 ± 16.2	12/6
Canbakan and Şahin [19]	2007	Turkey	Cross-sectional	44	CAPD	⁢36.2 ± 23.7	ICO	17	49.24 ± 13.25	10/7	N.A.
							GLU	27	46.81 ± 16.28	11/16
Lin et al. [20]	2009	China	RCT	201	CAPD	⁢1	ICO	98	56.8 ± 13.5	51/47	3
							GLU	103	55.4 ± 14.0	45/58
Paniagua et al. [14]	2009	México	RCT	59	N.A.	⁢12	ICO	30	58.9 ± 7.9	12/18	3
							GLU	29	60.5 ± 9.3	16/13
Amici et al. [21]	2001	Italy	Cross-sectional	27	CAPD	⁢17	ICO	15	64 ± 16	N.A.	N.A.
							GLU	12	60 ± 16	N.A.
Furuya et al. [22]	2006	Japan	Cross-sectional	24	CAPD/CCPD	⁢6	ICO	12	57.17 ± 8.68	5/7	N.A.
							GLU	12	57.67 ± 9.18	5/7
van Hoeck et al. [23]	2003	Belgium	Cross-sectional	16	NIPD	⁢0.25	ICO	8	5.75 ± 4.03	N.A.	N.A.
							GLU	8	5.75 ± 4.03	N.A.

Note: RCT: randomized controlled trial; APD: automated peritoneal dialysis; CAPD: continuous ambulatory peritoneal dialysis; NIPD: nocturnal intermittent peritoneal dialysis; N.A.: not applicable; ICO: icodextrin solution; GLU: standard glucose solution. Age appears as mean, mean ± standard deviation. Sex ratio: M = male, F = female.